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Oral Opioid Therapy for Chronic Peripheral and Central Neuropathic Pain
NEJM 348:1223-1232, 1279, Rowbotham,M.C.,et al, 2003
See this aricle in Pubmed

Article Abstract
The reduction in the intensity of neuropathic pain was significantly greater during treatment with higher doses of opioids than with lower doses. Higher doses produced more side effects without significant additional benefit in terms of other outcome measures.
 
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adverse drug reaction
opiate
pain
pain,management of chronic
pain,neuropathic
treatment of neurologic disorder

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